Keywords: Mechanochemistry
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Mechanochemical activation of metallic lithium for the generation and application of organolithium compounds in air
Here we report a mechanochemical method for the direct generation of organolithium reagents from readily available organic halides and unactivated lithium metal (lithium wire) under bulk-solvent-free conditions. These reactions rapidly generate a diverse array of organolithium compounds at room temperature without special precautions against moisture and without temperature control.
Kondo Keisuke, Koji Kubota, and Hajime Ito
Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides
A simple mechanochemical protocol for solid-state aromatic nucleophilic fluorination using potassium fluoride (KF) and quaternary ammonium salts was developed. This solid-state fluorination is fast and a variety of N-heteroaryl halides can be efficiently fluorinated within 1 h.
Koji Kubota, Tetsu Makino, Keisuke Kondo, Tamae Seo, Mingoo Jin, and Hajime Ito